MOTS-c Lyophilised Peptide
MOTS-c is a 16-residue peptide encoded by a short open reading frame within the mitochondrial 12S rRNA gene. It is classed as a mitochondrial-derived peptide and has been studied in cell and rodent models of metabolism, exercise and ageing. MOTS-c is supplied as a lyophilised (freeze-dried) powder in a sealed vial, in 10 mg and 40 mg sizes, priced RM 150–330. No certificate of analysis has been published for the batch on sale yet, so no purity figure is claimed on this page. Ships within 2 working days of payment. Sold for laboratory research use only, not for human or veterinary use.
Research use only. Sold for laboratory research only. Not for human or veterinary use, not for consumption, and not a medicine, food or cosmetic.
- Ships within 2 working days of payment.
- Free shipping across Malaysia.
- Pay by FPX online banking.
Certificates of analysis
No certificate of analysis has been published for the batch on sale yet, so this page makes no purity claim. Each certificate will name the testing laboratory, the batch, the test date and the method.
MOTS-c specifications
| Also known as | Mitochondrial open reading frame of the 12S rRNA-c, MOTS-c (human) |
|---|---|
| Form | Lyophilised (freeze-dried) powder in a sealed vial |
| Sizes | 10 mg · 40 mg |
| CAS number | 1627580-64-6 |
| Molecular formula | C101H152N28O22S2 |
| Molecular weight | 2,174.6 g/mol |
| Sequence | Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg (MRWQEMGYIFYPRKLR) |
| PubChem | CID 146675088 |
| Storage (sealed) | -20 °C (supplier specification; stability stated as ≥4 years) |
| Storage (reconstituted) | aqueous solutions not recommended for storage beyond one day (supplier insert) |
What research says about MOTS-c
MOTS-c is a 16-residue peptide encoded by a short open reading frame within the mitochondrial 12S rRNA gene. It is classed as a mitochondrial-derived peptide and has been studied in cell and rodent models of metabolism, exercise and ageing.
In cells it inhibits the folate cycle and de novo purine biosynthesis, leading to AMPK activation (Lee 2015), and it translocates to the nucleus under metabolic stress to regulate nuclear gene expression (Kim 2018).
Preclinical and early clinical: ClinicalTrials.gov lists a completed phase 1a/1b study of the MOTS-c-derived candidate CB4211 (NCT03998514, CohBar) and a recruiting phase 2 study of MOTS-c (NCT07505745); no marketing authorisation was identified.
Cited studies
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Reported a 16-amino-acid peptide from the mitochondrial 12S rRNA that, in mice, was associated with prevention of age-dependent and high-fat-diet-induced insulin resistance and diet-induced obesity.
The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.. Cell Metabolism, 2015. doi:10.1016/j.cmet.2015.02.009 · PubMed 25738459
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Showed AMPK-dependent nuclear translocation of MOTS-c and regulation of antioxidant-response genes during glucose restriction.
The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress.. Cell Metabolism, 2018. doi:10.1016/j.cmet.2018.06.008 · PubMed 29983246
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MOTS-c treatment was associated with higher physical performance in young, middle-aged and old mice, and exercise raised endogenous MOTS-c in human muscle and circulation.
MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis.. Nature Communications, 2021. doi:10.1038/s41467-020-20790-0 · PubMed 33473109
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Metabolomic analysis in diet-induced obese mice found reduced sphingolipid, monoacylglycerol and dicarboxylate metabolism pathways after MOTS-c injection.
The mitochondrial-derived peptide MOTS-c is a regulator of plasma metabolites and enhances insulin sensitivity.. Physiological Reports, 2019. doi:10.14814/phy2.14171 · PubMed 31293078
Handling and storage
- Sealed vial
- -20 °C (supplier specification; stability stated as ≥4 years)
- After reconstitution
- aqueous solutions not recommended for storage beyond one day (supplier insert)
Shipping, returns and payment
Dispatch. Ships within 2 working days of payment.
Shipping. Free shipping across Malaysia. Peninsular Malaysia 1–4 working days; Sabah, Sarawak and Labuan 3–7 working days.
Returns. No change-of-mind returns; a wrong or damaged item is replaced or refunded. Nothing here affects your rights under the Consumer Protection Act 1999.
Payment. FPX online banking.
Questions
- Is there a certificate of analysis for MOTS-c?
Not yet for the batch on sale. When one is published it appears in the certificates table on this page with the laboratory, batch, test date, method and result. See how to read a certificate of analysis.
- How is MOTS-c stored?
Sealed: -20 °C (supplier specification; stability stated as ≥4 years). After reconstitution: aqueous solutions not recommended for storage beyond one day (supplier insert). These are supplier figures, cited in the handling section.
