AOD9604 Lyophilised Peptide
AOD9604 is a synthetic 16-residue peptide derived from the C-terminal region (residues 177-191) of human growth hormone. It has been studied in rodent metabolic models and a rabbit joint model. AOD9604 is supplied as a lyophilised (freeze-dried) powder in a sealed vial, in 10 mg, priced RM 160. No certificate of analysis has been published for the batch on sale yet, so no purity figure is claimed on this page. Ships within 2 working days of payment. Sold for laboratory research use only, not for human or veterinary use.
Research use only. Sold for laboratory research only. Not for human or veterinary use, not for consumption, and not a medicine, food or cosmetic.
- Ships within 2 working days of payment.
- Free shipping across Malaysia.
- Pay by FPX online banking.
Certificates of analysis
No certificate of analysis has been published for the batch on sale yet, so this page makes no purity claim. Each certificate will name the testing laboratory, the batch, the test date and the method.
AOD9604 specifications
| Also known as | AOD-9604, LAT-8881, Anti-obesity Drug 9604, Tyr-hGH(177-191) |
|---|---|
| Form | Lyophilised (freeze-dried) powder in a sealed vial |
| Sizes | 10 mg |
| CAS number | 221231-10-3 |
| Molecular formula | C78H123N23O23S2 |
| Molecular weight | 1,815.1 g/mol |
| Sequence | Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe, cyclic (7->14) disulfide (16 residues; analogue of the C-terminal fragment 177-191 of human growth hormone with an added N-terminal Tyr) |
| PubChem | CID 71300630 |
| Storage (sealed) | -20 °C (supplier specification; stability stated as ≥4 years) |
What research says about AOD9604
AOD9604 is a synthetic 16-residue peptide derived from the C-terminal region (residues 177-191) of human growth hormone. It has been studied in rodent metabolic models and a rabbit joint model.
In obese mice it increased fat oxidation and plasma glycerol (an index of lipolysis) without competing for the hGH receptor or inducing cell proliferation (Heffernan 2001).
Investigational; no marketing authorisation was identified and a ClinicalTrials.gov search for 'AOD9604' returned no registered studies.
Cited studies
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In obese Zucker rats, 19 days of oral AOD9604 was associated with over 50% less body-weight gain than control and increased adipose lipolytic activity, with no adverse effect on insulin sensitivity.
Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone.. Hormone Research, 2000. doi:10.1159/000053183 · PubMed 11146367
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In ob/ob mice, AOD9604 reduced body-weight gain and raised fat oxidation without hyperglycaemia and did not bind the hGH receptor.
Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment.. International Journal of Obesity, 2001. doi:10.1038/sj.ijo.0801740 · PubMed 11673763
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In a collagenase-induced rabbit knee model, intra-articular AOD9604 was associated with lower cartilage-degeneration scores than saline, and lower still when combined with hyaluronic acid.
Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model.. Annals of Clinical and Laboratory Science, 2015. PubMed 26275694
Handling and storage
- Sealed vial
- -20 °C (supplier specification; stability stated as ≥4 years)
Shipping, returns and payment
Dispatch. Ships within 2 working days of payment.
Shipping. Free shipping across Malaysia. Peninsular Malaysia 1–4 working days; Sabah, Sarawak and Labuan 3–7 working days.
Returns. No change-of-mind returns; a wrong or damaged item is replaced or refunded. Nothing here affects your rights under the Consumer Protection Act 1999.
Payment. FPX online banking.
Questions
- Is there a certificate of analysis for AOD9604?
Not yet for the batch on sale. When one is published it appears in the certificates table on this page with the laboratory, batch, test date, method and result. See how to read a certificate of analysis.
- How is AOD9604 stored?
Sealed: -20 °C (supplier specification; stability stated as ≥4 years). These are supplier figures, cited in the handling section.
