Thymalin Lyophilised Peptide Extract
Thymalin is a polypeptide preparation obtained from calf thymus and described by the Khavinson group in St Petersburg. It is classed as a thymic peptide immunomodulator and has been studied in small, largely Russian-language clinical and cell-culture studies. Thymalin is supplied as a lyophilised (freeze-dried) powder in a sealed vial, in 10 mg, priced RM 160. No certificate of analysis has been published for the batch on sale yet, so no purity figure is claimed on this page. Ships within 2 working days of payment. Sold for laboratory research use only, not for human or veterinary use.
Research use only. Sold for laboratory research only. Not for human or veterinary use, not for consumption, and not a medicine, food or cosmetic.
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Certificates of analysis
No certificate of analysis has been published for the batch on sale yet, so this page makes no purity claim. Each certificate will name the testing laboratory, the batch, the test date and the method.
Thymalin specifications
| Also known as | Thymaline, thymus polypeptide extract |
|---|---|
| Form | Lyophilised (freeze-dried) powder in a sealed vial |
| Sizes | 10 mg |
What research says about Thymalin
Thymalin is a polypeptide preparation obtained from calf thymus and described by the Khavinson group in St Petersburg. It is classed as a thymic peptide immunomodulator and has been studied in small, largely Russian-language clinical and cell-culture studies.
Its activity has been attributed to short component peptides, with a 2023 study proposing that the dipeptides Lys-Glu (KE) and Glu-Trp (EW) in Thymalin reduce IL-1beta, IL-6 and TNF-alpha synthesis in human peripheral blood mononuclear cells in vitro.
Investigational as a research material in this record; no regulatory approval status was verified and the evidence base is small and from one research group.
Cited studies
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Thymalin and its KE and EW dipeptides reduced IL-1beta, IL-6 and TNF-alpha synthesis 1.4-6.0-fold in human PBMCs in an in vitro inflammation model, and modelling predicted binding to AKT1/AKT2-related genes.
The Influence of KE and EW Dipeptides in the Composition of the Thymalin Drug on Gene Expression and Protein Synthesis Involved in the Pathogenesis of COVID-19.. Int J Mol Sci, 2023. doi:10.3390/ijms241713377 · PubMed 37686182
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A report from the developing group described lower mortality over follow-up in older patients given Thymalin and Epithalamin than in controls; the abstract does not describe blinding, so it should be read with caution.
Peptides of pineal gland and thymus prolong human life.. Neuro Endocrinol Lett, 2003. PubMed 14523363
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Immunomorphological analysis detected thymalin in young human epidermal cells, and the thymalin-containing layer was thinner and discontinuous by about age 70.
Age-related changes of thymalin content in human epidermis.. Bull Exp Biol Med, 2002. doi:10.1023/a:1020214816056 · PubMed 12447484
Shipping, returns and payment
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Questions
- Is there a certificate of analysis for Thymalin?
Not yet for the batch on sale. When one is published it appears in the certificates table on this page with the laboratory, batch, test date, method and result. See how to read a certificate of analysis.